merck millipore,默克密理博,MABS167,Anti-Dab1 Antibody, clone EP2248Y, Rabbit,MABS167

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merck millipore,默克密理博,MABS167,Anti-Dab1 Antibody, clone EP2248Y, Rabbit,MABS167
产品名称：Anti-Dab1 Antibody, clone EP2248Y, Rabbit, MABS167
产品型号：MABS167
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Dab1 using this Anti-Dab1 Antibody, clone EP2 More>>

merck millipore,默克密理博,MABS167,Anti-Dab1 Antibody, clone EP2248Y, Rabbit,MABS167

产品介绍

merck millipore,默克密理博,MABS167,Anti-Dab1 Antibody, clone EP2248Y, Rabbit,MABS167

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, M	WB	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	MABS167
描述	Anti-Dab1 Antibody, clone EP2248Y, Rabbit \| MABS167
Alternate Names	disabled homolog 1 disabled homolog 1 (Drosophila) disabled (Drosophila) homolog 1
背景信息	Disabled-1 (Dab1) regulates laminar organization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abnormalities in neuronal positioning, migratory behavior linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adaptor in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral cortex and cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) (3).

产品信息
格式	Diluted Culture Supernatant
控制	Rat brain tissue lysate
演示	Rabbit Monoclonal in buffer containing 40% Glycerol, 50mM Tris-Glycine (pH 7.4), 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Dab1 using this Anti-Dab1 Antibody, clone EP2248Y, Rabbit validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Synthetic peptide corresponding to human Dab1 at Ser491.
表位	Ser491
克隆	EP2248Y
宿主	Rabbit
特异性	This antibody recognizes Dab1 at Ser491.
同种型	IgG
品种反应性	RatMouse
Species Reactivity Note	Demonstrated to react with Mouse and Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	O75553
基因符号	OTTHUMP00000011801 OTTHUMP00000010045 OTTHUMP00000011753
纯化方法	Unpurified
UniProt编号	O75553
UniProt汇总	FUNCTION: Adapter molecule functioning in neural development. May regulate SIAH1 activity By similarity. SUBUNIT STRUCTURE: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 By similarity. Interacts with LRP1. DOMAIN: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. PTM: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons By similarity. Also phosphorylated on Ser-524 independently of reelin signaling By similarity. SEQUENCE SIMILARITIES: Contains 1 PID domain. SEQUENCE CAUTION: The sequence BAE06094.1 differs from that shown. Reason: Erroneous initiation.

产品使用声明
质量保证	Evaluated by Western Blot in rat brain tissue lysate. Western Blot Analysis: A 1:2,000 dilution of this antibody detected Dab1 in rat brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.