merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB394-250UG,Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

  • merck millipore,默克密理博,MAB394-250UG,Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

    产品名称：Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2
    产品型号：MAB394-250UG
    Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in 0.

    merck millipore,默克密理博,MAB394-250UG,Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

  • 产品介绍
  • merck millipore,默克密理博,MAB394-250UG,Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RILMSaporinMonoclonal Antibody
    描述
    产品目录编号 MAB394-250UG
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2
    产品信息
    格式 Saporin
    演示 Saporin Conjugated. Sterile liquid. Provided in phosphate buffered saline. Contains no preservative.
    应用
    应用 Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in 0.
    主要应用
    • Immunolesioning
    应用说明 Immunotoxin
    生物信息
    克隆 4F10.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Dopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.
    同种型 IgG1
    品种反应性 Rat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000787.3
    Entrez基因汇总 The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
    基因符号
    • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
    • DBH
    • DBM
    UniProt编号
    • P09172
    UniProt汇总 FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
    COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
    SIZE: 617 amino acids; 69065 Da
    SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
    SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
    DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
    SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The material should be stored at -80°C for up to six months under sterile conditions. Avoid repeated freeze-thaw cycles.
    包装信息
    数量 250 µg

    merck millipore,默克密理博,MAB394-250UG,Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

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