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merck millipore,默克密理博,05-1567,Anti-p120 Catenin Antibody, clone 15D2
产品名称：Anti-p120 Catenin Antibody, clone 15D2
产品型号：05-1567
Use Anti-p120 Catenin Antibody, clone 15D2 (mouse monoclonal antibody) validated in WB, ICC, FC to detect p120 Catenin also known as Cadherin-associated Src substrate ,catenin (cadherin-associated pro More>>
merck millipore,默克密理博,05-1567,Anti-p120 Catenin Antibody, clone 15D2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M FC, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-1567 Replaces 04-237 描述 Anti-p120 Catenin Antibody, clone 15D2 Alternate Names - p120 catenin
- Cadherin-associated Src substrate
- catenin (cadherin-associated protein), delta 1
- catenin, delta 1
背景信息 p120 Catenin is a cadherin-associated protein that binds intracellular proteins, such as the small GTPase, RhoA, and controls E-cadherin funcation and stability. Proteins of the p120 family and their isoforms are expressed in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1. 产品信息 格式 Purified 控制 - Hela cell lysate.
演示 Purified mouse monoclonal in 0.1M Tris-Glycine (pH 7.4), 150mM NaCl and 0.05% sodium azide. 应用 应用 Use Anti-p120 Catenin Antibody, clone 15D2 (mouse monoclonal antibody) validated in WB, ICC, FC to detect p120 Catenin also known as Cadherin-associated Src substrate ,catenin (cadherin-associated protein) delta 1. 主要应用 - Flow Cytometry
- Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry: 生物信息 免疫原品种 Recombinant fusion protein derived from the C-terminus of murine p120 表位 C-terminus 克隆 clone 15D2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes p120 Catenin 同种型 IgG1κ 品种反应性 RatHumanMouse Species Reactivity Note Human and Mouse. Predicted to react with Rat based on homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - O60716
基因符号 - p120ctn
- CAS
- CTNND
- KIAA0384
- P120CAS
- p120
- P120CTN
- p120(cas)
- p120(ctn)
- p120cas
纯化方法 Protein G chromatography UniProt编号 - O60716
UniProt汇总 FUNCTION: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
SUBUNIT STRUCTURE: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membraneBy similarity. Note= Interaction with GLIS2 promotes nuclear translocation By similarity.
TISSUE SPECIFICITY: Expressed in vascular endothelium.
INDUCTION: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.
DOMAIN: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
PTM: Phosphorylated By similarity.
INVOLVEMENT IN DISEASE: May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.
SEQUENCE SIMILARITIES: Belongs to the beta-catenin family.
Contains 10 ARM repeats.
产品使用声明 质量保证 Evaluated by Western Blot on Hela cell lysate.
Western Blot Analysis: 1 g/mL of this antibody detected p120 Catenin in lysate from Hela cells.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
包装信息 数量 100 µg
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