merck millipore,默克密理愽
  • merck millipore,默克密理博,401481,IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem

  • merck millipore,默克密理博,401481,IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem

    产品名称：IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem
    产品型号：401481
    The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,401481,IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401481,IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₂H₁₀FN₃O₂S507475-17-4
    描述
    概述 A cell-permeable ureidocarboxamido thiophene compound that acts as a potent, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 18 nM) with selectivity over IKK-1, JNK and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Further reduces paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg per kg). A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401484) in DMSO is available.
    产品目录编号 401481
    品牌系列 Calbiochem®
    同义词 [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide, TPCA-1
    参考
    参考 Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
    Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
    Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
    产品信息
    CAS号 507475-17-4
    具有ATP竞争性 Y
    形式 Pale yellow solid
    Hill配方 C₁₂H₁₀FN₃O₂S
    化学配方 C₁₂H₁₀FN₃O₂S
    Molar Mass 279.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 IKK-2
    主靶IC50 18 nM against IKK-2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401481,IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem

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