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merck millipore,默克密理博,MAB3773,Anti-Annexin I Antibody, clone 6E4/3
产品名称：Anti-Annexin I Antibody, clone 6E4/3
产品型号：MAB3773
Anti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB.
merck millipore,默克密理博,MAB3773,Anti-Annexin I Antibody, clone 6E4/3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3773 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Annexin I Antibody, clone 6E4/3 Alternate Names - Lipocortin I, Calpactin II, Chromobindin 9, Phospholipase A2 Inhibitory Protein
- Lipocortin I
- Calpactin II
- Chromobindin 9
背景信息 Annexin I belongs to a family of Ca2+ dependent phospholipid binding proteins. It has been implicated in the regulation of phagocytosis, cell signaling and cell proliferation. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide 应用 应用 Anti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot
Immunofluorescence
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Whole native annexin proteins contained in a mixture of membrane proteins from human bone tissue 克隆 6E4/3 宿主 Mouse 特异性 Recognizes human Annexin I 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000700.1
Entrez基因汇总 Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. 基因符号 - p35
- ANXA1
- LPC1
- Annexin-1
- Chromobindin-9
- ANX1
UniProt编号 - P04083
UniProt汇总 FUNCTION: SwissProt: P04083 # Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
SIZE: 346 amino acids; 38714 Da
SUBUNIT: Homodimer in placenta (20%); linked by transglutamylation.
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).
DOMAIN: SwissProt: P04083 A pair of annexin repeats may form one binding site for calcium and phospholipid.
PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. 包装信息 数量 100 µg
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