- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MAB3632,Anti-PPAR gamma 1 and 2 Antibody, phospho-specific (Ser112)
产品名称：Anti-PPAR gamma 1 and 2 Antibody, phospho-specific (Ser112)
产品型号：MAB3632
Use Anti-PPAR gamma 1 & 2 Antibody, phospho-specific (Ser112) (mouse monoclonal antibody) validated in ELISA, WB, ICC to detect PPAR gamma 1 & 2 also known as Peroxisome Proliferator Activated Recepto More>>
merck millipore,默克密理博,MAB3632,Anti-PPAR gamma 1 and 2 Antibody, phospho-specific (Ser112)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, ELISA, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB3632 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PPAR gamma 1 and 2 Antibody, phospho-specific (Ser112) Alternate Names - PPARgamma1 and 2
产品信息 格式 Ascites 演示 Ascites. Liquid. Contains no preservative. 应用 应用 Use Anti-PPAR gamma 1 & 2 Antibody, phospho-specific (Ser112) (mouse monoclonal antibody) validated in ELISA, WB, ICC to detect PPAR gamma 1 & 2 also known as Peroxisome Proliferator Activated Receptor γ 1 & 2. 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
应用说明 Western blot: 1:500-1:5,000 on endogenous and recombinant protein.
Immunocytochemistry: 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Phosphorylated (serine 112) synthetic peptide from amino acids 107-121 of human PPAR gamma2 (identical to PPAR gamma1). No homology with PPAR alpha or PPAR beta. 表位 phospho-specific (Ser112) 宿主 Mouse 特异性 Recognizes phosphorylated Peroxisome Proliferator Activated Receptor (PPAR) gamma1 and gamma2. 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_138712.3
- NM_005037.5
- NM_015869.4
- NM_138711.3
Entrez基因汇总 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. 基因符号 - PPARG1
- PPARG
- NR1C3
- PPARG2
- PPAR-gamma
修改 - Phosphorylation
UniProt编号 - P37231
UniProt汇总 FUNCTION: SwissProt: P37231 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
SIZE: 505 amino acids; 57620 Da
SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary.
DISEASE: SwissProt: P37231 # Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. & Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]. & Defects in PPARG may be associated with colon cancer. & Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. & Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.
SIMILARITY: SwissProt: P37231 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,04-902,Anti-HA Tag Antibody, clone DW2, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,S20-KC,Rabbit Serum (1L) KC
相关产品
merck millipore,默克密理博,ABE501,Anti-phospho IRF3 (ser386) Antibody
merck millipore,默克密理博,14-531,EGFR Protein, active, 10 µg
merck millipore,默克密理博,AB19027,Anti-ADAM 17 Antibody
merck millipore,默克密理博,23-027M,b-catenin Protein, activated, 250 µg
merck millipore,默克密理博,04-902,Anti-HA Tag Antibody, clone DW2, rabbit monoclonal
merck millipore,默克密理博,S20-KC,Rabbit Serum (1L) KC
merck millipore,默克密理博,CB1036,Anti-S100A7 Mouse mAb (1A4)
merck millipore,默克密理博,07-861,Anti-phospho-PDGFRα (Tyr742) Antibody
merck millipore,默克密理博,MAB3084,Anti-Calpastatin Antibody, clone PI-11
merck millipore,默克密理博,SLHA033SB,Millex-HA 过滤器，0.45 µm，混合纤维素酯，33 mm，环氧乙烷灭菌