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merck millipore,默克密理博,MAB3462,Anti-Cyclooxygenase-2 Antibody, clone AS66
产品名称：Anti-Cyclooxygenase-2 Antibody, clone AS66
产品型号：MAB3462
Detect Cyclooxygenase-2 using this Anti-Cyclooxygenase-2 Antibody, clone AS66 validated for use in ELISA, FC & WB.
merck millipore,默克密理博,MAB3462,Anti-Cyclooxygenase-2 Antibody, clone AS66
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA, FC M Purified Monoclonal Antibody 描述 产品目录编号 MAB3462 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cyclooxygenase-2 Antibody, clone AS66 Alternate Names - COX II
背景信息 Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG), D2, PGE2, PGF2a, PG12 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activties. There are two enzymes of COX, COX 1 and COX 2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL-1 beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to action of prostaglandins produced by COX-2. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS with 0.08% sodium azide. 应用 应用 Detect Cyclooxygenase-2 using this Anti-Cyclooxygenase-2 Antibody, clone AS66 validated for use in ELISA, FC & WB. 主要应用 - Western Blotting
- ELISA
- Flow Cytometry
应用说明 Western blot: 1-5 μg/mL
ELISA
Flow cytometry
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Full length recombinant human Cox-2. 克隆 AS66 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Human Cyclooxygenase 2 (COX-2). 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000963.1
Entrez基因汇总 Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS2, which shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabit PTGS2 proteins, respectively. Human PTGS2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. The expression of this gene is deregulated in epithelial tumors. 基因符号 - EC 1.14.99.1
- PTGS2
- PHS-2
- COX-2
- hCox-2
- PGHS-2
- PGG/HS
- COX2
UniProt编号 - P35354
UniProt汇总 FUNCTION: SwissProt: P35354 # May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).
SIZE: 604 amino acids; 68996 Da
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein.
DISEASE:SwissProt: P35354 # Likely to play a role in inflammatory diseases such as rheumatoid arthritis.
SIMILARITY: SwissProt: P35354 ## Belongs to the prostaglandin G/H synthase family. & Contains 1 EGF-like domain.
MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase. & This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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