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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-617 品牌系列 Upstate
商名 - Upstate
描述 Anti-mGluR1 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide. 应用 应用 Anti-mGluR1 Antibody detects level of mGluR1 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 1180-1199 (C-PNVTYASVILRDYKQSSSTL) of rat mGluR1 宿主 Rabbit 特异性 mGluR1 同种型 IgG 品种反应性 Rat Species Reactivity Note predicted to cross-react with human and mouse based on sequence homology 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_058707
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. 基因符号 - MGLUR1
- GRM1
- MGLUR1A
- mGlu1
- GPRC1A
- mGluR1
- GRM1A
纯化方法 Protein A purfied UniProt编号 - Q13255
UniProt汇总 FUNCTION: SwissProt: Q13255 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
SIZE: 1194 amino acids; 132367 Da
SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: Q13255 ## Belongs to the G-protein coupled receptor 3 family.产品使用声明 质量保证 routinely evaluated by immunoblot on mGluR1 in rat brain microsomal preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µg
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