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merck millipore,默克密理博,MAB341,Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
产品名称：Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
产品型号：MAB341
Detect GABA A Receptor β 2 using this Anti-GABA A Receptor β 2, 3 Chain Antibody, clone BD17 validated for use in IH, IP & WB.
merck millipore,默克密理博,MAB341,Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Fe, B, H, M, R, Mk WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB341 Replaces AB5952 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17 Alternate Names - gamma-aminobutyric acid A receptor, beta 2
- GABA(A) receptor subunit beta-2
- gamma-aminobutyric acid (GABA) A receptor, beta 2
- beta 2
背景信息 Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines. 产品信息 格式 Purified 控制 - HepG2 cell lysate
演示 Purified mouse monoclonal IgG1 liquid in buffer containing 10 mM potassium phosphate buffer pH 7.4 with 150 mM NaCl 应用 应用 Detect GABA A Receptor β 2 using this Anti-GABA A Receptor β 2, 3 Chain Antibody, clone BD17 validated for use in IH, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry:
A 10-20 μg/mL concetration of a previous lot was used in IH.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified GABA/benzodiazepine receptor from bovine cortex 表位 Extracellular domain of the beta2 & beta3 subunits of the GABAA receptor 克隆 BD17 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with the β-chain of the GABAA receptor. 同种型 IgG1 品种反应性 FelineBovineHumanMouseRatMonkey Species Reactivity Note Expected to react with human and rat based on sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000813.2
Entrez基因汇总 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. 基因符号 - MGC119386
- GABRB2
- GABA
- MGC119388
- MGC119389
纯化方法 Protein A purfied UniProt编号 - P47870
UniProt汇总 FUNCTION: SwissProt: P47870 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 474 amino acids; 54606 Da
SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P47870 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family产品使用声明 质量保证 Evaluated by Western Blot on mouse brain membrane lysates.
Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µg
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