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merck millipore,默克密理博,MAB3320,Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5
产品名称:Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5
产品型号:MAB3320
Detect MMP-15 using this Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5 validated for use in WB, IH(P).
merck millipore,默克密理博,MAB3320,Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3320 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5 Alternate Names - MT2-MMP
产品信息 格式 Purified 演示 Liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. 应用 应用 Detect MMP-15 using this Anti-MMP-15 Antibody, catalytic domain, clone 162-22G5 validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunoblotting: 5-10 μg/mL.
Immunohistochemistry on paraffin-embedded tissue sections. Requires periodate-lyseine-paraformaldehyde fixation at 20 μg/mL, for 18-24 hours at 4°C.生物信息 表位 catalytic domain 克隆 162-22G5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody specifically reacts with mMT2-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of DTDNFQLPEDDLRG (residue 281-294) on mouse membrane-type 2 matrix metalloproteinase (MT2-MMP).
SPECIES REACTIVITY:
MAB3320 cross-reacts with human MT2-MMP.同种型 IgG1κ 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002428.2
Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. 基因符号 - EC 3.4.24.-
- MMP15
- MTMMP2
- MT2-MMP
- MT2MMP
- MMP-15
- SMCP-2
UniProt编号 - P51511
UniProt汇总 FUNCTION: SwissProt: P51511 # Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
SIZE: 669 amino acids; 75807 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
DOMAIN: SwissProt: P51511 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Manufactured by Daiichi Fine Chemical Co., Ltd
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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