merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3140,Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9

  • merck millipore,默克密理博,MAB3140,Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9

    产品名称：Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9
    产品型号：MAB3140
    Anti-Na+/H+ Exchanger-1 Antibody, C-terminus, clone 4E9 detects level of Na+/H+ Exchanger-1 & has been published & validated for use in WB.

    merck millipore,默克密理博,MAB3140,Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9

  • 产品介绍
  • merck millipore,默克密理博,MAB3140,Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ma, Vrt, F, Am, AvWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3140
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9
    Alternate Names
    • NHE1
    背景信息 Mammalian NHE (Na+/H+ Exchanger) is an integral membrane protein that is known to regulate intracellular pH by removing a proton in exchange for an extracellular sodium ion. There are nine known isofoms of NHE. The best characterized is NHE1, involved not only in intracellular pH control, but cell-volume control, cytoskeletal organization, heart disease and cancer. Transport by the NHE plays a pivotal role in the damage caused to the human myocardium during and following a myocardial infarction, and it is considered to represent a key step in the oncogenic transformation of cancerous cells. NHE comprises an N-terminal membrane domain that transports ions, and a C-terminal cytoplasmic domain that regulates activity and mediates cytoskeletal interactions. NHE2 - NHE5 isoforms are localized to the plasma membrane but exhibit greater tissue-specificity. NH2 and NH3 are more highly expressed in the kidney and intestine. Structurally, a single transmembrane segment from NHE1 has been solved, and the structure of bacterial Na+/H+ antiporter NhaA has been elucidated.
    产品信息
    格式 Purified
    控制
    • Kidney tissue (basolateral membrane)
    演示 Purified mouse monoclonal IgG1 liquid in buffer containing 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide
    应用
    应用 Anti-Na+/H+ Exchanger-1 Antibody, C-terminus, clone 4E9 detects level of Na+/H+ Exchanger-1 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    不建议的应用
    • Immunoprecipitation
    应用说明 Works poorly for immunohistochemistry and immunocytochemistry.
    Not recommended for immunoprecipitation.

    Immunoblotting:
    1:1,000 dilution used on a previous lot.

    Optimal working dilutions must be determined by the user.
    生物信息
    免疫原品种 MBP fusion protein containing the entire C-terminal, hydrophylic domain of porcine NHE1.
    表位 C-terminus
    克隆 4E9
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Na+/H+ exchanger, isoform NHE1
    同种型 IgG1
    品种反应性 MammalsVertebratesFishAmphibianAvian
    Species Reactivity Note All vertebrates including fish, amphibians, birds and mammals. Expected to react with rat and mouse based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003047.2
    基因符号
    • APNH1
    • SLC9A1
    • FLJ42224
    • APNH
    • NHE-1
    • Na
    • +H
    • NHE1
    纯化方法 Protein A purfied
    UniProt编号
    • P19634
    UniProt汇总 FUNCTION: SwissProt: P19634 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
    SIZE: 815 amino acids; 90763 Da
    SUBUNIT: Interacts with tescalcin, CHP and CHP2.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Kidney and intestine.
    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. & O-glycosylated.
    SIMILARITY: SwissProt: P19634 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family.
    MISCELLANEOUS: Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Human Kidney lysates.

    Western Blot:
    1:500 dilution of this lot detected Na+/H+ Exchanger-1 on 10 μg of Human Kidney lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3140,Anti-Na+/H+ Exchanger-1 Antibody, CT, clone 4E9

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