merck millipore,默克密理博,182707,AhR Antagonist III, GNF351

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Merck Millipore 默克密理愽

merck millipore,默克密理博,182707,AhR Antagonist III, GNF351 - Calbiochem
产品名称：AhR Antagonist III, GNF351 - Calbiochem
产品型号：182707

merck millipore,默克密理博,182707,AhR Antagonist III, GNF351 - Calbiochem

merck millipore,默克密理博,182707,AhR Antagonist III, GNF351 - Calbiochem

经验配方
C₂₄H₂₅N₇

描述
概述	A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 62 nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser³¹⁷, His²⁹¹, and Ser³⁶⁵ in human and with Ser³¹¹, His²⁸⁵, and Ser³⁵⁹ in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC₅₀ = 8.5 nM in HepG2 40/6 cells).
产品目录编号	182707
品牌系列	Calbiochem®
同义词	N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine, N-(2-(1H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methylpyridin-3-yl)-9H-purin-6-amine

参考
参考	Smith, K.J., et al. 2011. J. Pharmacol. Exp. Ther. 338, 318.

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,182707,AhR Antagonist III, GNF351 - Calbiochem

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