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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 04-035 Replaces 07-016 品牌系列 Upstate
商名 - Upstate
描述 Anti-PTEN Antibody, clone 6H2.1 背景信息 The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration. 产品信息 格式 Purified 演示 Protein G purified mouse IgG in storage buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-PTEN Antibody, clone 6H2.1 detects level of PTEN & has been published & validated for use in WB, IP, IH(P). 主要应用 - Western Blotting
生物信息 免疫原品种 C-terminal 100 amino acids of PTEN 表位 C-terminal region 克隆 6H2.1 宿主 Mouse 特异性 recognizes PTEN 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000305.3
基因符号 - TEP1
- PTEN
- MMAC1
纯化方法 Protein G purfied UniProt编号 - O08586 (mouse)
- P60484
产品使用声明 质量保证 routinely evaluated on HeLa cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,14-570,Ret Protein, active, 10 µg
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