merck millipore,默克密理博,480870,Neurotrophin Antagonist, Y1036

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Merck Millipore 默克密理愽

merck millipore,默克密理博,480870,Neurotrophin Antagonist, Y1036 - Calbiochem

经验配方
C₁₇H₁₄N₂O₆S₃

描述
概述	A furyl-thioxothiazolidinone compound that binds both BDNF (Cat. No. 203702) and NGF (Cat. No. 480352) (K_D = 3.5 and 3.0 µM, respectively) and prevents their interaction with cell surface receptors (IC₅₀ against BDNF/p75NTR, BDNF/trkB, NGF/p75NTR, and NGF/trkA interaction = 6.2, 3.7, 5.7, and 8.8 µM, respectively, in PC12 cultures), while exhibiting no effect against the receptor binding of the non-neurotrophin growth factors EGF and PDGF. Y1036 at 40 µM is shown to inhibit trkA and trkB phosphorylation upon 40 pM BDNF and NGF treatment, respectively, as well as downstream Erk phosphorylation. Y1036 is also demonstrated to block BDNF- and NGF-induced neurite outgrowth in rat embryonic dorsal-root ganglions in a dose-dependent manner.
产品目录编号	480870
品牌系列	Calbiochem®
同义词	3-[4-Oxo-5-[[5-(4-sulfamoylphenyl)-2-furyl]methylene]-2-thioxo-thiazolidin-3-yl]propanoic acid

参考
参考	Eibl, J.K., et al. 2009. J. Pharmacol. Exp. Ther. 332, 446.

生物信息
纯度	≥90% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,480870,Neurotrophin Antagonist, Y1036 - Calbiochem

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