merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2636,Anti-SERCA2 Antibody, clone IID8

  • merck millipore,默克密理博,MAB2636,Anti-SERCA2 Antibody, clone IID8

    产品名称：Anti-SERCA2 Antibody, clone IID8
    产品型号：MAB2636
    Anti-SERCA2 Antibody, clone IID8 is an antibody against SERCA2 for use in WB, IC, IH.

    merck millipore,默克密理博,MAB2636,Anti-SERCA2 Antibody, clone IID8

  • 产品介绍
  • merck millipore,默克密理博,MAB2636,Anti-SERCA2 Antibody, clone IID8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2636
    描述 Anti-SERCA2 Antibody, clone IID8
    Alternate Names
    • cardiac Ca2+ ATPase
    • Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
    • SR Ca(2+)-ATPase 2
    • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
    • Calcium pump 2
    • Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
    • Endoplasmic reticulum class 1/2 Ca(2+) ATPase
    背景信息 The sarcoplasmic reticulum of striated muscle is a specialized intracellular membrane system that plays a critical role in the contraction and relaxation of muscle. The sarco/endoplasmic reticulum Ca2+ ATPases (SERCAs) mediate Ca2+ uptake into intracellular stores. SERCA mediated Ca2+ uptake induces and maintains muscular relaxation. SERCA1 is expressed in fast-twitch muscles, whereas SERCA2 is expressed in cardiac and slow-twitch muscles. SERCA2 plays an important part in regulating cardiac contractile function.
    产品信息
    格式 Purified
    控制
    • HEK293 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-SERCA2 Antibody, clone IID8 is an antibody against SERCA2 for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Eizema, 2007).
    生物信息
    免疫原品种 Purified canine cardiac sarcoplasmic reticulum.
    表位 Unknown
    克隆 IID8
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody recognizes SERCA2.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001003214
    基因符号
    • SERCA2
    • ATP2A2
    • ATP2B
    • DAR
    • DD
    纯化方法 Protein G purfied
    UniProt编号
    • O46674
    UniProt汇总 FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle By similarity.

    CATALYTIC ACTIVITY: ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

    ENZYME REGULATION: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.

    SUBUNIT STRUCTURE: Associated with phospholamban (PLN). Isoform SERCA2B interacts with TRAM2 (via C-terminus). Interacts with HAX1 By similarity.

    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

    TISSUE SPECIFICITY: Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed.

    PTM: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity By similarity.

    SEQUENCE SIMILARITIES: Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate.

    Western Blot Analysis: 0.5 µg/ml of the antibody detected SERCA2 in 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2636,Anti-SERCA2 Antibody, clone IID8

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