merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5458,Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)

  • merck millipore,默克密理博,AB5458,Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)

    产品名称：Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)
    产品型号：AB5458
    This Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep) is validated for use in IH, WB for the detection of Neprilysin (Neutral Endopeptidase).

    merck millipore,默克密理博,AB5458,Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)

  • 产品介绍
  • merck millipore,默克密理博,AB5458,Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5458
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)
    Alternate Names
    • CD10
    • neprilysin
    • Neprilysin
    • Enkephalinase
    • enkephalinase
    • atriopeptidase
    • Atriopeptidase
    • Neutral Endopeptidase
    • NEP
    • Endopeptidase 24.11
    背景信息 Human neutral endopeptidase (Neprilysin) is single pass type II integral membrane endopeptidase that functions to activate and degrade biologically active enzymes. Endopeptidase,in general, function to cleave peptide bonds within enzyme sequences, in contrast to exopeptidases that target the end sequence. Neprilysin is part of the peptidase M13 family that acts on polypeptides of less than 30 amino acids with Thermolysin-like specificity for cleave sites. Thermolysin is thought to cleave before amino acids Ile, Met, Phe, Trpm or Val (unless Pro precedes) and after Ala, Asp, His, or Thr. Neprilysin preferentially cleaves polypeptides between hydrophobic residues, particularly with Phe or Tyr at position 1. Neprilysin research has found it important in the degradation of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Research has found it may function in the degradation of atrial natriuretic factor (ANF). Upregulation of ANF functions to regulate homeostatis of water, sodium, potassium and adipose in response to high blood pressure in muscle cells of the heart.
    产品信息
    格式 Serum
    控制
    • Kidney tissue.
    演示 Rabbit polyclonal serum. Contains no preservative.
    应用
    应用 This Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep) is validated for use in IH, WB for the detection of Neprilysin (Neutral Endopeptidase).
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western Blotting:
    A previous lot of this antibody was used on Western Blotting.

    Immunohistochemistry:
    A previous lot of this antibody was used on Immunohistochemistry.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Rat Neprilysin.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Neprilysin (Neutral Endopeptidase, NEP). On western blots of rat kidney extracts the antibody detects a band migrating at approximately 86 kDa corresponding to neprilysin.
    品种反应性 RatHumanMouse
    Species Reactivity Note Reacts with Human, Mouse, Rat. Reactivity with other species has not been confirmed.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000902.3
    Entrez基因汇总 This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
    基因符号
    • EC 3.4.24.11
    • MME
    • EPN
    • NEP
    • MGC126681
    • CD10
    • MGC126707
    • DKFZp686O16152
    • CALLA
    纯化方法 Unpurified
    UniProt编号
    • P08473
    UniProt汇总 FUNCTION: SwissProt: P08473 # Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).
    COFACTOR: Binds 1 zinc ion per subunit.
    SIZE: 750 amino acids; 85514 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
    DISEASE: SwissProt: P08473 # Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.
    SIMILARITY: SwissProt: P08473 ## Belongs to the peptidase M13 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5458,Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep)

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