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品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2625 描述 Anti-XB130 Antibody, clone 12 Alternate Names - AFAP1-like protein 2
- Actin filament associated protein 1-like 2
背景信息 XB130 is a 130 kDa adaptor protein and Src kinase substrate, structurally similar to actin-filament-associated protein. Recent evidence indicates tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85alpha. Importantly, downregulation of XB130 in TPC1 papillary thyroid cancer cells, harboring the RET/PTC1 kinase, strongly reduced Akt activity without altering ERK1/2 phosphorylation, and concomitantly inhibited cell-cycle progression and survival in suspension. XB130 is a novel substrate of the RET/PTC kinase that links RET/PTC signaling to PI 3-kinase activation, and thereby plays an important role in sustaining proliferation and survival of thyroid tumor cells, (Lodyga, 2009). 产品信息 格式 Purified 控制 - A549 cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-XB130 Antibody, clone 12 is validated for use in WB, IP, IC, ELISA, EA for the detection of XB130. 主要应用 - ELISA
- Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 His-tagged full length recombinant protein corresponding to human XB130. 表位 Unknown 克隆 12 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody recognizes XB130. 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_115939.1
基因符号 - KIAA1914
- XB130
- AFAP1L2
纯化方法 Protein G purfied UniProt编号 - Q8N4X5
UniProt汇总 FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
SUBUNIT STRUCTURE: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated.
SUBCELLULAR LOCATION: Cytoplasm
TISSUE SPECIFICITY: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas.
PTM: Tyrosine phosphorylated (by SRC).
SEQUENCE SIMILARITIES: Contains 2 PH domains.产品使用声明 质量保证 Evaluated by Western Blot on A549 cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected XB130 on 10 µg of A549 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,371209,Dkk-2, Mouse, Recombinant
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