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merck millipore,默克密理博,MAB2600,Anti-Glypican-1 Antibody, clone 4D1
产品名称：Anti-Glypican-1 Antibody, clone 4D1
产品型号：MAB2600
Anti-Glypican-1 Antibody, clone 4D1 detects level of Glypican-1 & has been published & validated for use in IH(P) & WB.
merck millipore,默克密理博,MAB2600,Anti-Glypican-1 Antibody, clone 4D1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB2600 描述 Anti-Glypican-1 Antibody, clone 4D1 Alternate Names - glypican proteoglycan 1
- glypican 1
背景信息 Heparan sulfate proteoglycans (HSPGs) can be divided into general categories of
cell-associated forms, including syndecans, glypicans, and secreted extracellular matrix forms, such as perlecan. Glypicans contain six family members to date and are proteins bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor and involved in cellular adhesion and migration and function as accessory molecules for signaling receptors, (Filmus, 2008 & Gui, 2006). Current publications indicate the main function of membrane-attached glypicans is to regulate the signaling of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs), (Filmus, 2008).
Glypican-1 (GPC1) is over-expressed in human gliomas and appears to have a greater capability of promoting FGF-2 signaling in some gliomas versus HSPGs in normal astrocytes. Additional observations suggest that GPC1 can impact the growth of pancreatic cancer cells by attenuating tumor angiogenesis, (Whipple, 2008).
产品信息 格式 Purified 控制 - PC-12 cell lysate.
演示 Purified in 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% NaN3. 应用 应用 Anti-Glypican-1 Antibody, clone 4D1 detects level of Glypican-1 & has been published & validated for use in IH(P) & WB. 主要应用 - Western Blotting
应用说明 Immunohistochemistry:
A 1:50 dilution of a previous lot detected strong cytoplasmic staining of tumor cells in formalin-fixed, paraffin-embedded gangliobastoma tissue sample. There was negative staining of normal, uninvolved cells.生物信息 免疫原品种 Full length recombinant protein. 表位 Full Length 克隆 4D1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 MAB2600 recognizes glypican-1. 同种型 IgG1κ 品种反应性 RatHuman Species Reactivity Note Human and rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002072
Entrez基因汇总 Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq].
基因符号 - glypican
- FLJ38078
纯化方法 Protein G purfied UniProt编号 - P35052
UniProt汇总 FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side.
Secreted glypican-1: Secreted › extracellular space.
PTM: This cell-associated glypican is further processed to give rise to a medium-released species.
SEQUENCE SIMILARITIES: Belongs to the glypican family.
产品使用声明 质量保证 Routinely evaluated by Western blot on human PC-12 cell lysate using 0.5 µg/mL of Anti-Glypican-1 at 1 mg/mL.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
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