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merck millipore,默克密理博,MABN37,Anti-Ataxin-1 Antibody, 11NQ, clone N76/8
产品名称：Anti-Ataxin-1 Antibody, 11NQ, clone N76/8
产品型号：MABN37
Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 detects level of Ataxin-1 & has been published & validated for use in IH.
merck millipore,默克密理博,MABN37,Anti-Ataxin-1 Antibody, 11NQ, clone N76/8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABN37 描述 Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 Alternate Names - ataxin-1
- ataxin 1
- Spinocerebellar ataxia type 1 protein
- spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
背景信息 Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons. 产品信息 格式 Purified 控制 - Rat hippocampus tissue
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 detects level of Ataxin-1 & has been published & validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Western Blot Analysis: A previous lot was used by an independent laboratory in rat brain tissue lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility)
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Ataxin-1 in rat cerebral cortex tissue.生物信息 免疫原品种 Linear peptide corresponding to mouse Ataxin-1. 克隆 N76/8 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 MouseRat Species Reactivity Note Demonstrated to react with rat. Predicted to react with mouse based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_033150
基因符号 - SCA1
- ATXN1
- ATX1
纯化方法 Protein G UniProt编号 - P54254
UniProt汇总 FUNCTION: May be involved in RNA metabolism.
SUBUNIT STRUCTURE: Homooligomer By similarity. Interacts with PQBP1, UBIN and USP7 By similarity. Interacts with ANP32A. Interacts with CIC and ATXN1L. Interacts with ZNF804A (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. Note: Colocalizes with USP7 in the nucleus (By similarity).
TISSUE SPECIFICTY: Widely expressed. In brain, the pattern of distribution is limited to neuron populations.
DEVELOPMENTAL STAGE: Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column.
DOMAIN: The AXH domain is required for interaction with CIC.
PTM: Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751 (By similarity).
POLYMORPHISM: The murine poly-Gln region is very limited in comparison to human ATXN1 and is not polymorphic.
SEQUENCE SIMILARITIES: Belongs to the ATXN1 family.
Contains 1 AXH domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in rat hippocampus tissue.
Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Ataxin-1 in rat hippocampus tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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