merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2256,Anti-Tropomyosin-5 Antibody, clone 2G10.2

  • merck millipore,默克密理博,MAB2256,Anti-Tropomyosin-5 Antibody, clone 2G10.2

    产品名称：Anti-Tropomyosin-5 Antibody, clone 2G10.2
    产品型号：MAB2256
    Anti-Tropomyosin-5 Antibody, clone 2G10.2 is an antibody against Tropomyosin-5 for use in WB, IH.

    merck millipore,默克密理博,MAB2256,Anti-Tropomyosin-5 Antibody, clone 2G10.2

  • 产品介绍
  • merck millipore,默克密理博,MAB2256,Anti-Tropomyosin-5 Antibody, clone 2G10.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2256
    描述 Anti-Tropomyosin-5 Antibody, clone 2G10.2
    Alternate Names
    • tropomyosin 5, pseudogene
    背景信息 Tropomyosins (Tms) are a family of over 40 highly conserved protein isoforms that result from alternative splicing of four different genes during development and that are expressed in numerous cell types. These proteins form coiled-coil heterodimers which bind to actin polymers along the α-helical grove. Tropomyosin’s function varies depending on cell type in which it is expressed. Within muscle, Tms play a role in the regulation of actin-myosin interplay for the purpose of mediating muscle contraction. In non-muscle cells, studies suggest a role in the stabilization of actin filaments, along with protecting actin filaments from the severing action of gelsolin and ADF/cofilin depolymerization. Tms also appear to have a role in the moderation of access to actin for other actin-binding proteins. Tropomyosin has an integral role in maintaining cardiovascular homeostasis. Down-regulation of Tms expression has been observed in tumor cells indicating a possible role for Tms as tumor suppressors.
    产品信息
    格式 Purified
    控制
    • Mouse brain tissue lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Tropomyosin-5 Antibody, clone 2G10.2 is an antibody against Tropomyosin-5 for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Tropomyosin-5 in human striated muscle tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to rat Tropomysosin-5.
    克隆 2G10.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 RatMouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rat based on immunogen design.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_476556
    Entrez基因汇总 Rod-like protein associated with actin filament in nonmuscle cells; may mediate the stability of actin filaments; may play a role in the regulation of cell transformation, cytokinesis, motility, and morphogenesis [RGD].
    基因符号
    • Tpm5
    • TPM5P
    纯化方法 Protein G
    UniProt编号
    • Q63610
    UniProt汇总 FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

    SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta chain. Binds to TMOD1 (By similarity).

    SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton.

    DOMAIN: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    SEQUECNE SIMILARITIES: Belongs to the tropomyosin family.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Tropomyosin-5 on 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2256,Anti-Tropomyosin-5 Antibody, clone 2G10.2

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