merck millipore,默克密理愽
  • merck millipore,默克密理博,489479,LSD1 Inhibitor IV, RN-1,HCl - Calbiochem

  • merck millipore,默克密理博,489479,LSD1 Inhibitor IV, RN-1,HCl - Calbiochem

    产品名称：LSD1 Inhibitor IV, RN-1,HCl - Calbiochem
    产品型号：489479
    The LSD1 Inhibitor IV, RN-1,HCl controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,489479,LSD1 Inhibitor IV, RN-1,HCl - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,489479,LSD1 Inhibitor IV, RN-1,HCl - Calbiochem

    重要规格表

    经验配方
    C₂₃H₂₉N₃O₂ • HCl
    描述
    概述 A cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.).
    产品目录编号 489479
    品牌系列 Calbiochem®
    同义词 Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, LSD Inhibitor IV
    参考
    参考 Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.
    产品信息
    形式 Yellow solid
    Hill配方 C₂₃H₂₉N₃O₂ • HCl
    化学配方 C₂₃H₂₉N₃O₂ • HCl
    Molar Mass 416
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 H₂O or DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,489479,LSD1 Inhibitor IV, RN-1,HCl - Calbiochem

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