merck millipore,默克密理博,MAB2168,Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,MAB2168,Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8
产品名称：Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8
产品型号：MAB2168
Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 is an antibody against Huntingtin Protein for use in ELISA, WB, IC, IH(P).

merck millipore,默克密理博,MAB2168,Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

产品介绍

merck millipore,默克密理博,MAB2168,Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Mk, H	ICC, ELISA, WB	M	Ascites	Monoclonal Antibody

描述
产品目录编号	MAB2168
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

产品信息
格式	Ascites
演示	Ascites fluid. Liquid, does not contain any preservative.

应用
应用	Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 is an antibody against Huntingtin Protein for use in ELISA, WB, IC, IH(P).
主要应用	Immunocytochemistry ELISA Western Blotting
应用说明	ELISA: 1:500-1:5,000 Western blot: 1:500-1:5,000 Immunohistochemistry on frozen and microwave oven treated paraffin sections (human tissue): 1:500-1:5,000 Immunocytochemistry on transfected cells: 1:500-1:5,000 Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Human huntingtin fragment from aa 2146 to 2541 as a fusion protein.
表位	a.a. 2146-2541
克隆	HU-2E8
宿主	Mouse
特异性	Reacts with Huntingtin protein from human and monkey. Weak to no reactivity with mouse. Has not been tested on other species.
同种型	IgG1
品种反应性	MonkeyHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002111.6
Entrez基因汇总	Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.
基因符号	HD HTT IT15 SLC6A4 Huntingtin OCD1
UniProt编号	P42858
UniProt汇总	FUNCTION: SwissProt: P42858 # May play a role in microtubule-mediated transport or vesicle function. SIZE: 3144 amino acids; 347860 Da SUBUNIT: Binds SH3GLB1 (By similarity). Interacts through its N- terminus with FNBP3. Interacts with PQBP1, SETD2 and SYVN. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. PTM: Cleaved by apopain downstream of the polyglutamine stretch. The resulting amino-terminal fragment is cytotoxic and provokes apoptosis. & Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation. DISEASE: SwissProt: P42858 # Defects in HD are the cause of Huntington disease (HD) [MIM:143100]. HD is an autosomal dominant neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia. Onset of the disease occurs usually in the third or fourth decade of life and symptoms progressively worsen leading to death in 10 to 20 years. Onset and clinical course depend on the degree of poly-Gln repeat expansion, longer expansions resulting in earlier onset and more severe clinical manifestations. HD affects 1 in 10,000 individuals of European origin. Neuropathology of Huntington disease displays a distinctive pattern with loss of neurons, especially in the caudate and putamen (striatum). SIMILARITY: SwissProt: P42858 ## Belongs to the hungtintin family. & Contains 10 HEAT repeats.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted aliquots up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.