merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4161,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

  • merck millipore,默克密理博,MAB4161,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

    产品名称：Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10
    产品型号：MAB4161
    Detect MDR1 using this Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10 validated for use in FC, IH(P).

    merck millipore,默克密理博,MAB4161,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

  • 产品介绍
  • merck millipore,默克密理博,MAB4161,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4161
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10
    Alternate Names
    • Pgp
    • P-glycoprotein
    • CD243
    • p170
    产品信息
    格式 Purified
    演示 Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
    应用
    应用 Detect MDR1 using this Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10 validated for use in FC, IH(P).
    主要应用
    • Flow Cytometry
    应用说明 Immunohistochemistry on formalin fixed paraffin embedded sections

    Confocal and Electron Microscopy

    ELISA

    Functional Studies (Cianfriglia, 2002)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Living intact human multidrug-resistant cells
    表位 extracellular human specific Pgp
    克隆 MM12.10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 MDR-1 clone MM12.10 recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Romagnoli, 1999).
    同种型 IgG2aκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000927.3
    Entrez基因汇总 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
    基因符号
    • EC 3.6.3.44
    • ABCB1
    • PGY1
    • MGC163296
    • GP170
    • ABC20
    • CD243
    • P-gp
    • MDR1
    • CLCS
    UniProt编号
    • P08183
    UniProt汇总 FUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
    SIZE: 1280 amino acids; 141463 Da
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
    SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4161,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

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