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merck millipore,默克密理博,MAB2035,Anti-Chondroitin 6 Sulfate Antibody, clone MK-302
产品名称：Anti-Chondroitin 6 Sulfate Antibody, clone MK-302
产品型号：MAB2035
Anti-Chondroitin 6 Sulfate Antibody, clone MK-302 is an antibody against Chondroitin 6 Sulfate for use in ELISA, RIA & WB.
merck millipore,默克密理博,MAB2035,Anti-Chondroitin 6 Sulfate Antibody, clone MK-302
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Sh, B, Ca, H, M, R, Rb WB, ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 MAB2035 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Chondroitin 6 Sulfate Antibody, clone MK-302 产品信息 格式 Ascites 演示 Ascites liquid; no preservative. 应用 应用 Anti-Chondroitin 6 Sulfate Antibody, clone MK-302 is an antibody against Chondroitin 6 Sulfate for use in ELISA, RIA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 ELISA at 1:100-1:5,000
RIA at 1:100-1:200.
Chondroitinase ABC digestion prior to antibody reaction is required for antibody reactivity. {0.5U/mL in 100mM Tris-HCL, 30 minutes room temperature} A dramatic proteolytic digestion of the core protein (e.g. with papain or pronase) significantly reduces the antibody reactivity.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Chondroitinase ABC-digested adult human aggrecan. 克隆 MK-302 宿主 Mouse 特异性 Reacts with a wide range of cartilage proteoglycans after either chondroitinase (ABC or AC) or testicular hyaluronidase digestion. Native proteoglycans do not react with MAB2035. Antibody binding to epitope is successfully inhibited by disaccharides of chondroitin-6-sulfate. Recognizes the chondroitin-6-sulfate stubs (preferentially in clusters) of high density cartilage proteoglycans of different species. No cross-reactivity with dermatan sulfate, keratan sulfate or chondroitin-4-sulfate. 同种型 IgG1 品种反应性 SheepBovineCanineHumanMouseRatRabbit 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_013227.2
- NM_001135.2
Entrez基因汇总 This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. 基因符号 - CSPGCP
- ACAN
- MSK16
- SEDK
- CSPCP
- AGCAN
- AGC1
- CSPG1
UniProt编号 - P16112
UniProt汇总 FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
SIZE: 2415 amino acids; 250193 Da
SUBUNIT: Interacts with FBLN1 (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Restricted to cartilages.
DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.
DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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