merck millipore,默克密理博,259545,Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0

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Merck Millipore 默克密理愽

merck millipore,默克密理博,259545,Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem

经验配方	CAS号
C₈H₂₂N₄O₄S	150333-69-0

描述
概述	A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (K_i = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
产品目录编号	259545
品牌系列	Calbiochem®
同义词	N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate

参考
参考	Lee, N.P., et al. 2010. Int J Cancer. 4, 968. Luchessi, A., et al. 2008. J Cell Physiol. 3, 480. Balabanov, S., et al. 2007. Blood. 4, 1701. Jakus, J., et al. 1993. J Biol Chem. 18, 13151.

生物信息
纯度	>95% by NMR

理化信息
溶解度	H₂O

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,259545,Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem

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