merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2029,Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27

  • merck millipore,默克密理博,MAB2029,Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27

    产品名称：Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27
    产品型号：MAB2029
    Detect Chondroitin Sulfate Proteoglycan using this Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27 validated for use in FC, IF & IP.

    merck millipore,默克密理博,MAB2029,Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27

  • 产品介绍
  • merck millipore,默克密理博,MAB2029,Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2029
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27
    产品信息
    格式 Purified
    演示 Purified from ascites by Protein A Sepharose™ chromatography. Purified immunoglobulin in 0.02M PBS pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
    应用
    应用 Detect Chondroitin Sulfate Proteoglycan using this Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27 validated for use in FC, IF & IP.
    主要应用
    • Flow Cytometry
    应用说明 Immunofluorescence microscopy of cells in culture (Bumoi et al., 1984; Schrappe et al., 1992). Also, Legg J et al (2003) Development 130:6049-6063 {3% PFA fixed frozen sections}.

    Immunoelectron microscopy (Bumoi et al., 1984)

    Immunoprecipitation: 1μg/10E6 cells (Bumoi et al., 1984; Morgan et al., 1981)

    FACS analysis: 1-2μg/10E6 cells

    Functional block of melanoma cell spreading (Morgan et al., 1981), glioma cell proliferation3 and tumor growth in nude mice (Morgan et al., 1981; Schrappe et al., 1992).

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human M14 melanoma cell extract depleted of fibronectin and bound by lens culinaris lectin-Sepharose™ (Morgan et al., 1981).
    克隆 9.2.27
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes mature chondroitin sulfate proteoglycan core glycoprotein of 250 kDa as well as precursor polypeptides of 210, 220 and 240 kDa (Bumoi et al., 1984). Reacts with human melanoma, glioma and proliferating brain endothelial cells.
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001897.4
    Entrez基因汇总 A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
    基因符号
    • HMW-MAA
    • CSPG4
    • MSK16
    • MCSP
    • NG2
    • MCSPG
    • MEL-CSPG
    UniProt编号
    • Q6UVK1
    UniProt汇总 FUNCTION: SwissProt: Q6UVK1 # Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

    SIZE: 2322 amino acids; 250497 Da

    SUBUNIT: Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.

    SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).

    TISSUE SPECIFICITY: Detected only in malignant melanoma cells.

    PTM: N-glycosylated (By similarity). & O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4. & Phosphorylation by PRKCA regulates its subcellular location and function in cell motility (By similarity).

    SIMILARITY: SwissProt: Q6UVK1 ## Contains 15 CSPG (NG2) repeats. & Contains 2 laminin G-like domains.

    MISCELLANEOUS: Valuable marker for several incompletely differentiated precursor cells.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain between 2 and 8°C in undiluted aliquots for up to 6 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2029,Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27

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