merck millipore,默克密理愽
  • merck millipore,默克密理博,17-439,RalB Activation Assay Kit (non-radioactive)

  • merck millipore,默克密理博,17-439,RalB Activation Assay Kit (non-radioactive)

    产品名称：RalB Activation Assay Kit (non-radioactive)
    产品型号：17-439
    Non-radioactive Ral-B Activation Assay Kit can be used to precipitate Ral-B-GTP from cell lysates & detection by a Ral-B specific monoclonal antibody.

    merck millipore,默克密理博,17-439,RalB Activation Assay Kit (non-radioactive)

  • 产品介绍
  • merck millipore,默克密理博,17-439,RalB Activation Assay Kit (non-radioactive)

    重要规格表

    品种反应性 主要应用
    R, H, MGPA
    描述
    产品目录编号 17-439
    品牌系列 Upstate
    商名
    • Upstate
    描述 RalB Activation Assay Kit (non-radioactive)
    Alternate Names
    • GTP binding protein
    • RAS-like protein B
    • v-ral simian leukemia viral oncogene homolog B
    产品信息
    部件
    • 100X GDP, 100mM (Cat.# 20-177)
    • anti-RalB, clone 25 (Cat.# 04-037)
    • Ral Assay Reagent (Ral BP1, agarose) (Cat.# 14-415)
    • Mg2+ Lysis/Wash Buffer, 5X (Cat.# 20-168)
    • 100X GTPγS, 10mM (Cat.# 20-176)
    应用
    应用 Non-radioactive Ral-B Activation Assay Kit can be used to precipitate Ral-B-GTP from cell lysates & detection by a Ral-B specific monoclonal antibody.
    主要应用
    • G-Protein Assay
    生物信息
    品种反应性 RatHumanMouse
    Entrez基因编号
    • NM_006788.3
    基因符号
    • RALBP1
    • RLIP1
    • RIP1
    • RalBP1
    • RIP
    • RLIP76
    UniProt编号
    • Q15311
    UniProt汇总 FUNCTION: SwissProt: Q15311 # Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
    SIZE: 655 amino acids; 76063 Da
    SUBUNIT: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDC2 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.
    SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
    TISSUE SPECIFICITY: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
    SIMILARITY: SwissProt: Q15311 ## Contains 1 Rho-GAP domain.
    产品使用声明
    质量保证 Routinely evaluated by non-radioactive Kinase Assay.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C from date of shipment
    包装信息
    数量 20 assays

    merck millipore,默克密理博,17-439,RalB Activation Assay Kit (non-radioactive)

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