merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1998Z,Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free

  • merck millipore,默克密理博,MAB1998Z,Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free

    产品名称：Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free
    产品型号：MAB1998Z
    This Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free is validated for use in FC, IH, IP, FUNC for the detection of Integrin α2β1.

    merck millipore,默克密理博,MAB1998Z,Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free

  • 产品介绍
  • merck millipore,默克密理博,MAB1998Z,Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, HIHC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1998Z
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free
    Alternate Names
    • MAB1998
    • VLA-2
    产品信息
    格式 Purified
    控制
    • Skin, CD4 & CD8 positive T cells
    演示 Purified immunoglobulin from Protein A chromatography. Liquid in 0.02M PB pH 7.6, 0.25M NaCl containing no preservative.
    应用
    应用 This Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free is validated for use in FC, IH, IP, FUNC for the detection of Integrin α2β1.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 flow cytometry: 10 μg/mL

    Immunoprecipitation: Immunoprecipitation of VLA-2 integrins from lysate of 10E6 cell equivalent requires 2-5 μg of BHA2.1

    immunohistochemistry in frozen tissue sections: 5 μg/mL

    Does not detect alpha2 integrin subunit by Western blot presumably due to conformational properties of the epitope involved. The epitope for BHA2.1 is dependent on the presence of the (I) domain of alpha2 integrin subunit and does not bind VLA-2 variant which lacks the I-domain.

    Function Blocking: BHA2.1 inhibits VLA-2 mediated cell adhesion to collagen and laminin; complete inhibition can generally be achieved at a final concentration of 10 μg/mL.

    Final working dilutions must be determined by end user.
    生物信息
    克隆 BHA2.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the collagen receptor VLA-2 (alpha2beta1) integrin complex.
    同种型 IgG1κ
    品种反应性 PigHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002203.3
    Entrez基因汇总 This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
    基因符号
    • GPIa
    • ITGA2
    • CD49B
    • VLAA2
    • VLA-2
    • CD49b
    • BR
    纯化方法 Protein A purfied
    UniProt编号
    • P17301
    UniProt汇总 FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    SIZE: 1181 amino acids; 129295 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1998Z,Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free

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