merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1969,Anti-Integrin α5β1 Antibody, clone JBS5

  • merck millipore,默克密理博,MAB1969,Anti-Integrin α5β1 Antibody, clone JBS5

    产品名称：Anti-Integrin α5β1 Antibody, clone JBS5
    产品型号：MAB1969
    Anti-Integrin α5β1 Antibody, clone JBS5 is an antibody against Integrin α5β1 for use in IH, IH(P) & IP.

    merck millipore,默克密理博,MAB1969,Anti-Integrin α5β1 Antibody, clone JBS5

  • 产品介绍
  • merck millipore,默克密理博,MAB1969,Anti-Integrin α5β1 Antibody, clone JBS5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, HIHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1969
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α5β1 Antibody, clone JBS5
    Alternate Names
    • VLA-5
    背景信息 Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 15 alpha and 8 beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. The alpha-3 subunit (CD49c) is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. The alpha-3 subunit exists in two different splice variants, denoted as "A" and "B". The only difference that results from this differential splicing is a total change in the cytoplasmic domain, while the extracellular domain stays the same. Knock-out mice lacking this subunit show prenatal lethality and abnormalities in the kidneys.
    产品信息
    格式 Ascites
    控制
    • Mouse 3T3 fibroblasts Skin (Basement Membrane)
    演示 Ascites fluid containing no preservatives.
    应用
    应用 Anti-Integrin α5β1 Antibody, clone JBS5 is an antibody against Integrin α5β1 for use in IH, IH(P) & IP.
    主要应用
    • Immunohistochemistry
    应用说明 Immunoprecipitation: 1-2 μg

    Induction of homotypic aggregation: 100 pg/mL

    Immunohistochemistry with paraformaldehyde fixation.

    Paraffin embedded, PFA fixed tissue in monkey 1:50 with HIER {Qin et al., 2003}.

    Inhibition of adhesion to fibronectin

    Optimal dilutions must be determined by end user.
    生物信息
    免疫原品种 Jurkat Cells
    克隆 JBS5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the human integrin alpha5beta1.
    同种型 IgG1
    品种反应性 MonkeyHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002205.2
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    基因符号
    • FNRA
    • ITGA5
    • VLA-5
    • CD49e
    • VLA5A
    纯化方法 Unpurified
    UniProt编号
    • P08648
    UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1049 amino acids; 114536 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1969,Anti-Integrin α5β1 Antibody, clone JBS5

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下一件merck millipore产品：merck millipore,默克密理博,MAB8151-K,Anti-West Nile Virus/Kunjin, Envelope, Clone 3.91D (1mg)


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