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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB1945 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Vitronectin Antibody, clone BV2 Alternate Names - S-protein
- Serum spreading factor
产品信息 格式 Purified 演示 Purified immunoglobulin by Protein A chromatography. Liquid in PBS containing 0.02% sodium azide and 0.1% BSA. 应用 应用 Anti-Vitronectin Antibody, clone BV2 is an antibody against Vitronectin for use in ELISA, FC, IP, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Flow Cytometry
- Western Blotting
应用说明 ELISA
Immunoprecipitation
Western blot
Immunohistochemistry/immunofluorescence
Inhibits endothelial cell adhesion and spreading on vitronectin-coated surfaces.
Flow Cytometry
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified human plasma vitronectin (Preissner, 1985). 克隆 BV2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Human vitronectin. Specificity determined by ELISA and immunoprecipitation of I125 labeled vitronectin purified from plasma (Zanetti et al., 1994). The antibody reacts with vitronectin both in its native and denatured form. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000638.3
Entrez基因汇总 The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. 基因符号 - V75
- VTN
- S-protein
- epibolin
- VNT
- VN
UniProt编号 - P04004
UniProt汇总 FUNCTION: SwissProt: P04004 # Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
SIZE: 478 amino acids; 54306 Da
SUBUNIT: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
SUBCELLULAR LOCATION: Secreted, extracellular space.
TISSUE SPECIFICITY: Plasma.
DOMAIN: SwissProt: P04004 The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
PTM: Sulfated on 2 tyrosine residues. & N- and O-glycosylated (By similarity). & Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. & It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SIMILARITY: Contains 4 hemopexin-like domains. & Contains 1 SMB (somatomedin-B) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. 包装信息 数量 100 µg
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