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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE792 描述 Anti-FAM120A Antibody Alternate Names - Protein FAM120A
- Constitutive coactivator of PPAR-gamma-like protein 1
- Oxidative stress-associated Src activator
背景信息 Constitutive coactivator of PPAR-gamma-like protein 1, also known as Oxidative stress-associated Src activator or Protein FAM120A, and encoded by the gene name FAM120A or OSSA, was recently detected within the Purα-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A is highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-FAM120A Antibody is an antibody against FAM120A for use in western blotting, IHC & immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected FAM120A in rat brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected FAM120A in rat brain cells.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the N-terminus of human FAM120A. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody will not cross-reacti with FAM120B/PGCC1. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody 基因符号 - OSSA
- FAM120A
- C9orf10
- KIAA0183
纯化方法 Antigen Affinity purified UniProt编号 - Q9NZB2
产品使用声明 质量保证 Evaluated by Western Blotting in SK-N-SH cell lysate.
Western Blotting Analysis: 0.5 μg/mL of this antibody detected FAM120A in SK-N-SH cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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