merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1914P,Anti-Laminin gamma 1 Antibody, clone A5

  • merck millipore,默克密理博,MAB1914P,Anti-Laminin gamma 1 Antibody, clone A5

    产品名称：Anti-Laminin gamma 1 Antibody, clone A5
    产品型号：MAB1914P
    Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).

    merck millipore,默克密理博,MAB1914P,Anti-Laminin gamma 1 Antibody, clone A5

  • 产品介绍
  • merck millipore,默克密理博,MAB1914P,Anti-Laminin gamma 1 Antibody, clone A5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIH(P)RPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1914P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Laminin gamma 1 Antibody, clone A5
    Alternate Names
    • LAMC1
    背景信息 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.
    产品信息
    格式 Purified
    控制
    • Tubular carcinoma of the colon and fibroneuroma
    演示 Purified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
    应用
    应用 Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    生物信息
    免疫原品种 Basement membrane protein preparation from mouse EHS tumor.
    克隆 A5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2aκ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    基因符号
    • LAMC1
    纯化方法 Protein G purfied
    UniProt编号
    • P11047
    UniProt汇总 FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (EHS laminin), laminin-2 (merosin), laminin-3 (S-laminin), laminin-4 (S-merosin), laminin-6 (K-laminin) and laminin-7 (KS-laminin).
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
    TISSUE SPECIFICITY: Found in the basement membranes (major component).
    DOMAIN: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    DOMAIN: Domains VI and IV are globular.
    SIMILARITY: Contains 11 laminin EGF-like domains.
    SIMILARITY: Contains 1 laminin IV type A domain.
    SIMILARITY: Contains 1 laminin N-terminal domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1914P,Anti-Laminin gamma 1 Antibody, clone A5

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