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merck millipore,默克密理博,MAB1675,Anti-Cytokeratin 19 Antibody, clone E6
产品名称:Anti-Cytokeratin 19 Antibody, clone E6
产品型号:MAB1675
Anti-Cytokeratin 19 Antibody, clone E6 detects level of Cytokeratin 19 & has been published & validated for use in WB, IH.
merck millipore,默克密理博,MAB1675,Anti-Cytokeratin 19 Antibody, clone E6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 F, R, Rb IHC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1675 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytokeratin 19 Antibody, clone E6 产品信息 格式 Ascites 演示 Liquid 应用 应用 Anti-Cytokeratin 19 Antibody, clone E6 detects level of Cytokeratin 19 & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry frozen tissue sections.
Immunoblotting
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Keratin from rat colon. 克隆 E6 宿主 Mouse 特异性 Rat keratin 19 (40kD), analogous to human keratin 19. 同种型 IgG1 品种反应性 FishRatRabbit 抗体类型 Monoclonal Antibody Entrez基因汇总 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. 非反应性品种 - Mouse
- Human
UniProt编号 - Q63279
- P08727
UniProt汇总 FUNCTION: SwissProt: P08727 # Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
SIZE: 400 amino acids; 44092 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
TISSUE SPECIFICITY: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.DEVELOPMENTAL STAGE: Present in hair follicles at all stages of development.
DOMAIN: SwissProt: P08727 This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
SIMILARITY: Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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