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merck millipore,默克密理博,MAB1534,Anti-Hexokinase Type I Antibody, NT, clone 4D4
产品名称：Anti-Hexokinase Type I Antibody, NT, clone 4D4
产品型号：MAB1534
Detect Hexokinase Type I using this Anti-Hexokinase Type I Antibody, N-terminus, clone 4D4 validated for use in IH(P) & WB.
merck millipore,默克密理博,MAB1534,Anti-Hexokinase Type I Antibody, NT, clone 4D4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, M WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1534 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Hexokinase Type I Antibody, NT, clone 4D4 产品信息 格式 Ascites 应用 应用 Detect Hexokinase Type I using this Anti-Hexokinase Type I Antibody, N-terminus, clone 4D4 validated for use in IH(P) & WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:500-1:2,000.
Blocks binding of Type I hexokinase to mitochondria.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rat Type I hexokinase. 表位 N-terminus 克隆 4D4 宿主 Mouse 特异性 Recognizes a segmental epitope at the extreme N-terminus of the Type I hexokinase sequence. 同种型 IgG1 品种反应性 RatBovineMouse 抗体类型 Monoclonal Antibody Entrez基因汇总 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. UniProt编号 - P05708
- P19367
UniProt汇总 SIZE: 917 amino acids; 102486 Da
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.
TISSUE SPECIFICITY: Isoform 2 is erythrocyte specific; isoform 3 and isoform 4 are testis-specific.
DOMAIN: SwissProt: P19367 The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
DISEASE:SwissProt: P19367 # Defects in HK1 are the cause of hexokinase deficiency [MIM:235700]. Hexokinase deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
SIMILARITY: Belongs to the hexokinase family.
MISCELLANEOUS: In vertebrates there are four major glucose- phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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