merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5873,Anti-Catechol O-methyltransferase Antibody

  • merck millipore,默克密理博,AB5873,Anti-Catechol O-methyltransferase Antibody

    产品名称：Anti-Catechol O-methyltransferase Antibody
    产品型号：AB5873
    This Anti-Catechol O-methyltransferase Antibody is validated for use in WB for the detection of Catechol O-methyltransferase.

    merck millipore,默克密理博,AB5873,Anti-Catechol O-methyltransferase Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5873,Anti-Catechol O-methyltransferase Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5873
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Catechol O-methyltransferase Antibody
    Alternate Names
    • COMT
    产品信息
    格式 Serum
    控制
    • POSITIVE CONTROL:

      Human liver homogenate.
    演示 Liquid.
    应用
    应用 This Anti-Catechol O-methyltransferase Antibody is validated for use in WB for the detection of Catechol O-methyltransferase.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:5,000-1:10,000 using ECL. Suggested antibody dilution buffer is 25 mM Tris HCl. Suggested blocking buffer is 25 mM Tris HCl with 150mM NaCl and 5% milk.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human recombinant COMT.
    宿主 Rabbit
    特异性 COMT (Catechol o-methyltransferase). By Western blot the antibody recognizes the 25 kDa soluble COMT and the 30 kDa membrane bound COMT.

    SPECIES REACTIVITIES:

    Human. It is expected that the antibody will also react with rodent COMT but reactivity has not been confirmed. Other species have not yet been tested.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_007310.1
    • NM_000754.2
    Entrez基因汇总 Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.
    基因符号
    • EC 2.1.1.6
    • COMT
    • catechol-O-methyltransferase
    UniProt编号
    • P21964
    UniProt汇总 FUNCTION: SwissProt: P21964 # Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
    COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
    SIZE: 271 amino acids; 30037 Da
    SUBCELLULAR LOCATION: Isoform Soluble: Cytoplasm. & Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
    TISSUE SPECIFICITY: Brain, liver, placenta, lymphocytes and erythrocytes.
    PTM: The N-terminus is blocked.
    SIMILARITY: SwissProt: P21964 ## Belongs to the mammalian catechol-O-methyltransferase family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5873,Anti-Catechol O-methyltransferase Antibody

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