merck millipore,默克密理博,07-1673,Anti-SOX1 Antibody

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merck millipore,默克密理博,07-1673,Anti-SOX1 Antibody
产品名称：Anti-SOX1 Antibody
产品型号：07-1673
Use Anti-SOX1 Antibody (Rabbit Polyclonal Antibody) validated in IHC(P) to detect SOX1 also known as SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1.

merck millipore,默克密理博,07-1673,Anti-SOX1 Antibody

产品介绍

merck millipore,默克密理博,07-1673,Anti-SOX1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H, M	IH(P)	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1673
描述	Anti-SOX1 Antibody
Alternate Names	SRY-related HMG-box gene 1 SRY (sex determining region Y)-box 1
背景信息	Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

应用
应用	Use Anti-SOX1 Antibody (Rabbit Polyclonal Antibody) validated in IHC(P) to detect SOX1 also known as SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1.
主要应用	Immunohistochemistry (Paraffin)

生物信息
免疫原品种	Synthetic peptide corresponding to SOX1.
宿主	Rabbit
特异性	This antibody recognizes SOX1.
品种反应性	HumanMouse
Species Reactivity Note	Human. Predicted to react with mouse based on sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_009233
基因符号	SRY SOX1
纯化方法	Affinity Purfied
UniProt编号	O00570
UniProt汇总	FUNCTION: Transcriptional activator By similarity. SUBCELLULAR LOCATION: NucleusProbable. TISSUE SPECIFICITY: Mainly in the developing central nervous system. SIMILARITY: Contains 1 HMG box DNA-binding domain.

产品使用声明
质量保证	Evaluated by immunohistochemistry on human epidermis. Immunohistochemistry(paraffin): A 1:300 dilution of this antibody was used to detect SOX1 in human epidermis.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8ºC from date of receipt. To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10 μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.

储存和货运信息

存储条件

Stable for 1 year at 2-8ºC from date of receipt.
To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10 μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.