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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB1077 描述 Anti-DYNLT3 Antibody, clone 10A3C8A1 Alternate Names - t-complex-associated-testis-expressed 1-like
- Protein 91/23
- T-complex-associated testis-expressed 1-like
- dynein, light chain, Tctex-type 3
背景信息 Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These motor proteins contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (microtubules in the case of the kinesin family and dyneins) In all cell types, dynein is a large protein complex composed of six distinct subunits and is responsible for most intracellular movement toward the minus ends of microtubules. Cytoplasmic dynein has many important roles in transporting membrane bound organelles, including endosomes, lysosomes, and mitochondria. It is also involved in the positioning of the centrosome, the nucleus, and the Golgi. Cytoplasmic dynein is also responsible for virus transport to the nucleus, retrograde axonal transport, and microtubule and neurofilament transport.
Three families of dynein light chains (DYNLT) have been identified. Two isoforms of the DYNLT family of light chains, DYNLT1 and DYNLT3, have been proposed to link dynein to specific cargoes. Recent publications indicate that DYNLT3 binds to Bub3, a spindle checkpoint protein and Bub3 binds exclusively to DYNLT3 and not to other dynein light chains. DYNLT3 is present on kinetochores at prometaphase, but not later mitotic stages.It has been suggested that a subpopulation of dynein, containing the DYNLT3 light chain, may have a role in the transport of checkpoint proteins from the kinetochore to the spindle pole, (W.-Ho, 2007).产品信息 格式 Purified 控制 - Rat brain lysate
演示 Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3. 应用 应用 This Anti-DYNLT3 Antibody, clone 10A3C8A1 is validated for use in WB, IH for the detection of DYNLT3. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Full-length recombinant rat DYNLT3 protein 克隆 10A3C8A1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with rat DYNLT3 (dynein light chain Tctex-type 3). 同种型 IgG2aκ 品种反应性 RatHumanMouse Species Reactivity Note Reacts with rat and human. Other species have not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001013246.1
基因符号 - TCTEX1L
- RP3
- TCTE1L
- TCTE1XL
纯化方法 Protein G purfied UniProt编号 - Q5XI90
产品使用声明 质量保证 Evaluated on a representative lot by Western blot in rat brain lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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