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merck millipore,默克密理博,IHCR2014-6,IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14
产品名称：IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14
产品型号：IHCR2014-6
This IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14 is validated for use in IH(P) for the detection of Neuron-Specific Enolase.
merck millipore,默克密理博,IHCR2014-6,IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14
- 产品介绍
- merck millipore,默克密理博,IHCR2014-6,IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IH(P) M Purified Monoclonal Antibody 描述 产品目录编号 IHCR2014-6 商名 - Chemicon
- IHC Select
描述 IHC Select® Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14 Alternate Names - NSE
产品信息 格式 Purified 演示 Monoclonal mouse antibody supplied in liquid format as tissue culture supernatant, diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as a preservative. 应用 应用 This IHC Select Anti-Neuron-Specific Enolase Antibody, prediluted, clone BBS/NC/VI-H14 is validated for use in IH(P) for the detection of Neuron-Specific Enolase. 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.
Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.
Incubation: 10 minutes with IHC Select® Detection Kits.
NSE has been prediluted for use as the primary antibody with Chemicon's IHC Select® Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used.生物信息 免疫原品种 Gamma-gamma enolase purified from human brain 克隆 BBS/NC/VI-H14 宿主 Mouse 特异性 Reacts with human gamma-gamma enolase (Mr 46000). This antibody does not cross react with alpha or beta subunits of NSE. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001975.2
Entrez基因汇总 This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. 基因符号 - EC 4.2.1.11
- ENO2
- NSE
- Gamma-enolase
UniProt编号 - P09104
UniProt汇总 FUNCTION: SwissProt: P09104 # Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
COFACTOR: Magnesium. Required for catalysis and for stabilizing the dimer.
SIZE: 434 amino acids; 47269 Da
SUBUNIT: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity).
TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.DEVELOPMENTAL STAGE: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.
SIMILARITY: SwissProt: P09104 ## Belongs to the enolase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C . Refer to vial for expiration dating. 包装信息 数量 6 mL
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