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merck millipore,默克密理博,09-872,Anti-Methylcytosine dioxygenase TET1 Antibody
产品名称：Anti-Methylcytosine dioxygenase TET1 Antibody
产品型号：09-872
Anti-Methylcytosine dioxygenase TET1 Antibody is a Rabbit Polyclonal Antibody for detection of Methylcytosine dioxygenase TET1 also known as tet oncogene 1 & has been validated in WB, ChIP-seq.
merck millipore,默克密理博,09-872,Anti-Methylcytosine dioxygenase TET1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-872 描述 Anti-Methylcytosine dioxygenase TET1 Antibody Alternate Names - Leukemia-associated protein with a CXXC domain
- tet oncogene 1
- Ten-eleven translocation 1 gene protein
- CXXC-type zinc finger protein 6
- methylcytosine dioxygenase TET1
- CXXC finger 6
- ten-eleven translocation-1
背景信息 Methylcytosine dioxygenase TET1 (mTET1) is a member of the TET family and contains a characteristic CXXC-type zinc finger domain. mTET1 binds methylcytosine (5mC), a minor, mammalian DNA base necessary to development and retrotransposon silencing, and acts as a catalyst to induce the conversion of 5mC to 5-hydromethylcytosine (hmC or 5hmC), a mammalian DNA base thought to be involved in chromatin structure and in the development of fetal brain, heart and lung tissues. Recent studies indicate that mTET1 regulates the levels of 5hmC, thereby influencing patterns in DNA methylation. 产品信息 格式 Affinity Purified 控制 - Mouse embryonic stem cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Methylcytosine dioxygenase TET1 Antibody is a Rabbit Polyclonal Antibody for detection of Methylcytosine dioxygenase TET1 also known as tet oncogene 1 & has been validated in WB, ChIP-seq. 主要应用 - Western Blotting
应用说明 Western Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse Methylcytosine dioxygenase TET1 near the C-terminus. 表位 Near the C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes methylcytosine dioxygenase TET1 near the C-terminus. 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse.
Other homologies: Rat (66% sequence homology), Human (61% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_081660
基因符号 - CXXC6
- TET1
- LCX1
纯化方法 Affinity Purified UniProt编号 - Q3URK3
UniProt汇总 FUNCTION: Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain (By similarity).
CATALYTIC ACTIVITY: Methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.
COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SEQUENCE SIMILARITIES: Belongs to the TET family.
Contains 1 CXXC-type zinc finger.
SEQUENCE CAUTION: The sequence BAB27288.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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