merck millipore,默克密理愽
  • merck millipore,默克密理博,HTS099RTA,Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells

  • merck millipore,默克密理博,HTS099RTA,Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells

    产品名称：Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells
    产品型号：HTS099RTA
    Human EP1 GPCR frozen cells for Calcium Flux FLIPR Assays.

    merck millipore,默克密理博,HTS099RTA,Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells

  • 产品介绍
  • merck millipore,默克密理博,HTS099RTA,Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells

    重要规格表

    品种 宿主细胞 蛋白靶
    HumanChem-1EP1
    描述
    产品目录编号 HTS099RTA
    商名
    • Ready-to-Assay
    描述 Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells
    背景信息 Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

    Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects (Narumiya and FitzGerald, 2001). The prostaglandin PGE2 causes pain, vasodilation, immunosuppression of T cells, bone resorption and promotion of carcinogenesis. Four related GPCRs, EP1, EP2, EP3 and EP4, each bind to PGE2, but the different G protein coupling status of each receptor leads to distinct biological effects; EP1 couples primarily to Gq to mobilize intracellular calcium. EP1 appears to mediate the effects of PGE2 in promoting formation of precancerous lesions in animal models of colon cancer (Watanabe et al., 1999). In addition, EP1 has an inhibitory effect on stress-induced aggressive and risk-taking behaviors in mice (Matsuoka et al., 2005). Chemicon's cloned human EP1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant EP1 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to enhance coupling of the receptor to the calcium signaling pathway.
    产品信息
    部件
    • Fifty (50) mL of Media Component.
    • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
    应用
    应用 Human EP1 GPCR frozen cells for Calcium Flux FLIPR Assays.
    生物信息
    品种 Human
    GPCR类别 A
    宿主细胞 Chem-1
    蛋白靶 EP1
    靶子系列 Prostanoid
    细胞系类型
    • Ready-to-Assay
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.
    储存和货运信息
    存储条件 Place cells in liquid nitrogen immediately upon receipt.
    包装信息
    数量 1 kit

    merck millipore,默克密理博,HTS099RTA,Ready-to-Assay™ EP1 Prostanoid Receptor Frozen Cells

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