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  • merck millipore,默克密理博,AB3127,Anti-FLT-4 Antibody

  • merck millipore,默克密理博,AB3127,Anti-FLT-4 Antibody

    产品名称：Anti-FLT-4 Antibody
    产品型号：AB3127
    Detect FLT-4 using this Anti-FLT-4 Antibody validated for use in ELISA & WB.

    merck millipore,默克密理博,AB3127,Anti-FLT-4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3127,Anti-FLT-4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3127
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-FLT-4 Antibody
    Alternate Names
    • VEGF Receptor-3
    产品信息
    格式 Affinity Purified
    演示 Liquid in PBS, containing 0.1% BSA. Affinity purified immunoglobulin.
    应用
    应用 Detect FLT-4 using this Anti-FLT-4 Antibody validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL. The antibodies detected ~140 kDa band in rat liver extracts.

    ELISA: 1:10,000-1:100,000, using 50-100ng of control peptide/well.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 20 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse Flt-4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes mouse Flt-4 (mouse 1363-aa and human 1298-aa) a receptor protein tyrosine kinase. It is type 1 membrane protein, a receptor for VEGF-C and is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta. Flt-4 is also known as vascular endothelial growth factor receptor 3 (VEGFR3).

    SPECIES REACTIVITIES: The peptide sequence used is relatively conserved in rat (85%) and human (73%) Flt-4/VEGFR3. No significant sequence homology is seen with VEGFR1, VEGFR2, or other tyrosine kinases. Antibody crossreactivity in other species is not established.
    品种反应性 Mouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_182925.3
    • NM_002020.3
    基因符号
    • EC 2.7.10.1
    • FLT4
    • PCL
    • VEGFR-3
    • FLT41
    • VEGFR3
    UniProt编号
    • P35916
    UniProt汇总 FUNCTION: SwissProt: P35916 # Receptor for VEGFC. Has a tyrosine-protein kinase activity.
    SIZE: 1298 amino acids; 145599 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
    DISEASE: SwissProt: P35916 # Defects in FLT4 are the cause of hereditary lymphedema I [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. & Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
    SIMILARITY: SwissProt: P35916 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze and thaw.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3127,Anti-FLT-4 Antibody

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