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merck millipore,默克密理博,HTMP2MAG-54K,MILLIPLEX MAP Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
产品名称：MILLIPLEX MAP Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
产品型号：HTMP2MAG-54K
The analytes available for this multiplex kit are: TIMP-1, TIMP-2, TIMP-3, TIMP-4.
merck millipore,默克密理博,HTMP2MAG-54K,MILLIPLEX MAP Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
- 产品介绍
- merck millipore,默克密理博,HTMP2MAG-54K,MILLIPLEX MAP Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 TIMP-4, TIMP-1, TIMP-2, TIMP-3 H Mplex Luminex xMAP 描述 产品目录编号 HTMP2MAG-54K 商名 - MILLIPLEX
描述 MILLIPLEX MAP Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay 概述 MILLIPLEX® MAP Human TIMP Magnetic Bead Panels enable you to explore the modulation of TIMP expression and the function of the MMP/TIMP in a variety of therapeutic areas. Human TIMP Panel 1 Magnetic Bead kit (TIMP-1, -2) is to be used for serum/plasma samples, while Human TIMP Panel 2 Magnetic Bead kit (TIMP-1, -2, -3, -4) has been designed for tissue/cell culture samples. Both panels are in a convenient “all-in-one” box format to give you the assurance that you will have all the necessary reagents you need to run your assay. Both panels are customizable, allowing you to choose the TIMPs that best fit your needs. 背景信息 Tissue Inhibitors of Metalloproteinases (TIMPs) comprise a family of four inhibitors known as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Each member of the TIMP family has its own distinct profile of metalloproteinase inhibition. The matrix metalloproteinases (MMPs) are a family of zinc proteases involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, tissue and bone remodeling, wound healing, tissue morphogenesis, angiogenesis, and tumor metastasis. MMPs are also known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), cell proliferation, differentiation and chemokine in/activation. The normal function of MMPs must be precisely regulated by their endogenous protein inhibitors, TIMPs . TIMPs inhibit MMPs by forming 1:1, non-covalent complexes with MMPs, thereby blocking access of substrates to the MMP catalytic site. Except for inhibition of active MMPs, TIMPs also exhibit several other biochemical and physiological/biological functions such as proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Disruption of the MMP/TIMP balance can result in serious diseases such as arthritis, cardiovascular disorders, tumor growth and metastasis. 产品信息 检测方法 Luminex xMAP 配置 Design your multiplex kit by choosing analytes. 精度（%） - Inter-assay: < 10
- Intra-assay: < 10
板面类型 MAGNETIC Cytokines/Chemokines 应用 应用 The analytes available for this multiplex kit are: TIMP-1, TIMP-2, TIMP-3, TIMP-4. 主要应用 - Multiplexing
应用说明 • This is a 2-hour or overnight assay requiring 25 μL urine, tissue and cell culture samples. Overnight incubation is recommended. 生物信息 品种反应性 Human 可用的分析物 - TIMP-4
- TIMP-1
- TIMP-2
- TIMP-3
交叉反应性 No significant cross-reactivity was observed among analytes in this panel. 准确度 - 77% - 95%
理化信息 灵敏度 - Refer to kit protocol for sensitivities of individual analytes.
标准曲线范围 - TIMP-4: 10 - 10,000 pg/mL
- TIMP-1: 20 - 20,000 pg/mL
- TIMP-2: 49 - 50,000 pg/mL
- TIMP-3: 98 - 100,000 pg/mL
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C. 包装信息 数量 96-well plate
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