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merck millipore,默克密理博,GF310,PDGF-BB Protein, Human Recombinant Animal Free
产品名称：PDGF-BB Protein, Human Recombinant Animal Free
产品型号：GF310
The Platelet derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. Recombinant animal free human PDGF-BB is manufactured using all non-animal More>>
merck millipore,默克密理博,GF310,PDGF-BB Protein, Human Recombinant Animal Free
- 产品介绍
重要规格表
来源 纯度 E. coli Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses 描述 产品目录编号 GF310 描述 PDGF-BB Protein, Human Recombinant Animal Free Alternate Names - Proto-oncogene c-Sis
- Platelet Derived Growth Factor-BB
- Platelet Derived Growth Factor
- PDGF-2
- Platelet-derived growth factor B chain
- Platelet-derived growth factor beta polypeptide
背景信息 Platelet derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the αgranules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGFAA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). 产品信息 配方 演示 Product is filtered through a 0.2 micron filter before lyophilization. 应用 应用 The Platelet derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. Recombinant animal free human PDGF-BB is manufactured using all non-animal reagents. 生物信息 纯度 Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses 来源 E. coli 交叉反应性 Cow, Monkey, Mouse, Pig, Rat UniProt编号 - P01127
产品使用声明 质量保证 Bioactivity assay: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. 储存和货运信息 存储条件 Store at -20°C for up to 6 months from date of receipt. 包装信息 数量 10 µg
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