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merck millipore,默克密理博,GF073,Stromal Cell-Derived Factor-1α Protein, Recombinant human
产品名称：Stromal Cell-Derived Factor-1α Protein, Recombinant human
产品型号：GF073
The Stromal Cell-Derived Factor-1alpha protein (or SDF1alpha protein) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines.
merck millipore,默克密理博,GF073,Stromal Cell-Derived Factor-1α Protein, Recombinant human
- 产品介绍
重要规格表
主要应用 品种 来源 纯度 CULT Human E.coli Greater than 98% by SDS-PAGE and HPLC analysis 描述 产品目录编号 GF073 品牌系列 Chemicon®
商名 - Chemicon
描述 Stromal Cell-Derived Factor-1α Protein, Recombinant human 概述 Stromal Cell-Derived Factor-1alpha (SDF1alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. GF073 is a 8.0 kDa protein containing 68 amino acid residues. Alternate Names - SDF-1alpha
产品信息 演示 Lyophilized protein with no additives. 应用 应用 The Stromal Cell-Derived Factor-1alpha protein (or SDF1alpha protein) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. 主要应用 - Cell Culture
生物信息 纯度 Greater than 98% by SDS-PAGE and HPLC analysis 来源 E.coli 品种 Human 特异活性 BIOLOGICAL ACTIVITY: <br /><br />Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20.0-80.0 ng/mL. Entrez基因编号 - NM_199168.2
- NM_000609.4
- NM_001033886.1
Entrez基因汇总 For background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM] 基因符号 - SDF-1a
- CXCL12
- SDF1A
- TLSF-b
- TPAR1
- SDF-1b
- TLSF
- SDF-1
- SDF1
- PBSF
- TLSF-a
- SDF1B
- SCYB12
- hIRH
UniProt编号 - P48061
UniProt汇总 FUNCTION: SwissProt: P48061 # Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.
SIZE: 93 amino acids; 10666 Da
SUBCELLULAR LOCATION: Secreted.
PTM: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
SIMILARITY: SwissProt: P48061 ## Belongs to the intercrine alpha (chemokine CxC) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1-1 mg/mL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum. Reconstituted SDF1alpha should be stored at 4°C or in undiluted aliquots at -20°C for up to 6 months. 包装信息 数量 10 µg
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