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  • merck millipore,默克密理博,07-491,Anti-Kv4.2 Antibody

  • merck millipore,默克密理博,07-491,Anti-Kv4.2 Antibody

    产品名称：Anti-Kv4.2 Antibody
    产品型号：07-491
    Detect Kv4.2 using this Anti-Kv4.2 Antibody validated for use in WB.

    merck millipore,默克密理博,07-491,Anti-Kv4.2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-491,Anti-Kv4.2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Vrt, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-491
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Kv4.2 Antibody
    产品信息
    格式 Affinity Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect Kv4.2 using this Anti-Kv4.2 Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acids 23-42 of rat Kv.4.2 protein, with a C-terminal cysteine added for conjugation purposes.
    宿主 Rabbit
    特异性 Kv4.2,
    同种型 IgG
    品种反应性 VertebratesRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_012281
    Entrez基因汇总 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.
    基因符号
    • MGC119703
    • KCND2
    • KV4.2
    • RK5
    • KIAA1044
    • MGC119702
    • Kv4.2
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q9NZV8
    UniProt汇总 FUNCTION: SwissProt: Q9NZV8 # Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
    SIZE: 630 amino acids; 70537 Da
    SUBUNIT: Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and FREQ (By similarity). Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.
    TISSUE SPECIFICITY: Highly expressed throughout the brain. Expression is very low or absent in other tissues.DOMAIN:SwissProt: Q9NZV8 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    PTM: Phosphorylated on serine and threonine residues (By similarity).
    SIMILARITY: Belongs to the potassium channel family. D (Shal) subfamily.
    产品使用声明
    质量保证 routinely evaluated by immunoblot in in rat brain membrane preperations
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-491,Anti-Kv4.2 Antibody

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