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merck millipore,默克密理博,FCMAB389F,Milli-Mark™ Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4
产品名称：Milli-Mark™ Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4
产品型号：FCMAB389F
Milli-Mark Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4 is an antibody against Integrin β1 for use in FC.
merck millipore,默克密理博,FCMAB389F,Milli-Mark™ Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB389F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4 Alternate Names - CLIBS
- Ligand-induced Binding Site
- LIBS
背景信息 Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits 1 to 6 (CD49a to CD49f) also known as Very Late Antigens (VLA). CD29 is also called platelet GPIIa. The antigen mediates cellular adhesion and has broad cellular reactivity, but is not expressed by erythrocytes. In normal peripheral blood it is found on a subset of CD4+ and CD8+ T lymphocytes and on a minority of B lymphocytes. The "inducer" subpopulation of CD4+ lymphocytes co-express CD4 and CD29. 产品信息 格式 FITC 控制 - A431 cells
演示 Purified mouse monoclonal IgG2b conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4 is an antibody against Integrin β1 for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Generated against human beta1 integrins purified from Triton X-100 lysates of human lung, liver, and skeletal muscle tissues. 克隆 HUTS-4 宿主 Mouse 特异性 Antibody recognizes Integrin β1. 同种型 IgG2b 品种反应性 Human Species Reactivity Note Tested and passed on Human. Unconjugated antibody Cat. No. MAB2079Z is known to react with Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002202
基因符号 - LAMS
- LAMB2
- S-laminin
纯化方法 Protein A Purified UniProt编号 - P05556
UniProt汇总 FUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 798 amino acids; 88465 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.
TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).
SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.产品使用声明 质量保证 Evaluated by flow cytometry using A431 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
上一件merck millipore产品：merck millipore,默克密理博,FCMAB269F,Milli-Mark™ Anti-Integrin β1 (CD29)-FITC conjugate Antibody, clone MB1.2
下一件merck millipore产品：merck millipore,默克密理博,539734,PTP, Yersinia enterocolitica, Recombinant, E. coli
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