merck millipore,默克密理博,FCMAB381A4,Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2

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merck millipore,默克密理博,FCMAB381A4,Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2
产品名称：Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2
产品型号：FCMAB381A4
Detect IGF-I using this Milli-Mark Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2 validated for use in FC.

merck millipore,默克密理博,FCMAB381A4,Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2

产品介绍

merck millipore,默克密理博,FCMAB381A4,Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	AlexaFluor®488	Monoclonal Antibody

描述
产品目录编号	FCMAB381A4
商名	Milli-Mark
描述	Milli-Mark™ Anti-IGF-I-Alexa Fluor® 488 Antibody, clone Sm1.2
Alternate Names	insulin-like growth factor 1 (somatomedin C): somatomedin C Mechano growth factor insulin-like growth factor 1
背景信息	Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5b. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues. The signal is transduced by intracellular events. IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

产品信息
格式	AlexaFluor®488
控制	MCF-7 cells
演示	Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Detect IGF-I using this Milli-Mark Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2 validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Human insulin-like growth factor I (IGF-I) purified from human plasma.
克隆	Sm1.2
宿主	Mouse
特异性	Antibody recognizes IGF-I
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Tested and passed on Human. Unconjugated antibody Cat. No. 05-172 is known to react with Mouse, Rat, and Avian.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000609
Entrez基因汇总	The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
基因符号	MGF IGF1 IBP1 IGFI IGF-IA
纯化方法	Protein G Purified
UniProt编号	P05019
UniProt汇总	FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.\| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. SIZE: 195 amino acids; 21841 Da SUBCELLULAR LOCATION: Secreted. DOMAIN: SwissProt: P05019 DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.\| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.\| P01343 ## Belongs to the insulin family.

产品使用声明
质量保证	Evaluated by flow cytometry unsing MCF-7 cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB381A4,Milli-Mark™ Anti-IGF-I-Alexa Fluor 488 Antibody, clone Sm1.2

上一件merck millipore产品：merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25
下一件merck millipore产品：merck millipore,默克密理博,ABC128,Anti-Angiogenin Antibody

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