merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25

  • merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25

    产品名称：Anti-PTP-PEST Antibody, clone AG25
    产品型号：05-1417
    Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.

    merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25

  • 产品介绍
  • merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25

    Replacement Information
    Replacement Information 05-1417 is a recommended replacement for MAB3739

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 05-1417
    Replaces MAB3739
    描述 Anti-PTP-PEST Antibody, clone AG25
    Alternate Names
    • Protein tyrosine phosphatase, non-receptor type 12
    • Protein-tyrosine phosphatase G1
    • Tyrosine-protein phosphatase non-receptor type12
    • Protein tyrosine phosphatase
    背景信息 The protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
    产品信息
    格式 Ascites
    控制
    • HeLa cell lysate
    演示 Mouse monoclonal IgG1 ascites containing no preservatives.
    应用
    应用 Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunoprecipitation: Recommended.

    Immunocytochemistry: Recommended.
    生物信息
    免疫原品种 Baculovirus expressed purified human PTP-PEST
    克隆 AG25
    宿主 Mouse
    特异性 Recognizes human PTP-PEST.
    同种型 IgG1
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, mouse and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002835
    Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
    基因符号
    • EC 3.1.3.48
    • PTPN12
    • PTPG1
    • PTP-PEST
    UniProt编号
    • Q05209
    UniProt汇总 SIZE: 780 amino acids; 88120 Da
    SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
    SUBCELLULAR LOCATION: Cytoplasm.
    DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
    SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on HeLa lysates.

    Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
    Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-1417,Anti-PTP-PEST Antibody, clone AG25

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