merck millipore,默克密理博,ABC418,Anti-PALB2 Antibody

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merck millipore,默克密理博,ABC418,Anti-PALB2 Antibody
产品名称：Anti-PALB2 Antibody
产品型号：ABC418
Detect Partner & localizer of BRCA2 using this rabbit polyclonal antibody, Anti-PALB2 Antibody validated for use in western blotting.

merck millipore,默克密理博,ABC418,Anti-PALB2 Antibody

产品介绍

merck millipore,默克密理博,ABC418,Anti-PALB2 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC418
描述	Anti-PALB2 Antibody
Alternate Names	PALB2 Partner and localizer of BRCA2
背景信息	Partner and localizer of BRCA2 (PALB2) is the critical protein required for the homologous recombination repair at DNA breaks. It serves as a scaffold protein in the formation of the BRAC1-PALB2-BRAC2 complex which is essential for homologous recombination. Essentially a partner of BRAC2, PALB2 localizes BRAC2 and stabilizes it. PALB2 enables BRAC2 to perform its recombinational repair and checkpoint functions in addition to its DNA repair functions. Also by binding BRAC2, PALB2 is thought to help BRCA2 avoid degradation. PALB2 localizes to the nucleus and has at least four known isoforms. Defects in PALB2 are linked with many forms of breast cancers, pancreatic cancer type 3 (PNCA3), as well as disorders of the bone marrow (Fanconi anemia complementation group, FANCN). These patients suffer numerous cardiac, limb, and skin malformations as well as malignancies.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Detect Partner & localizer of BRCA2 using this rabbit polyclonal antibody, Anti-PALB2 Antibody validated for use in western blotting.
主要应用	Western Blotting

生物信息
免疫原品种	GST-tagged fusion protein corresponding to human PALB2.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	FANCN PALB2
纯化方法	Antigen Affinity purified
UniProt编号	Q86YC2

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: A 1:500 dilution of this antibody detected PALB2 in HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.