merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL306,Anti-β-2 Microglobulin Antibody, clone C21

  • merck millipore,默克密理博,CBL306,Anti-β-2 Microglobulin Antibody, clone C21

    产品名称：Anti-β-2 Microglobulin Antibody, clone C21
    产品型号：CBL306
    Detect β-2 Microglobulin using this Anti-β-2 Microglobulin Antibody, clone C21 validated for use in ELISA.

    merck millipore,默克密理博,CBL306,Anti-β-2 Microglobulin Antibody, clone C21

  • 产品介绍
  • merck millipore,默克密理博,CBL306,Anti-β-2 Microglobulin Antibody, clone C21

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL306
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-β-2 Microglobulin Antibody, clone C21
    背景信息 Beta2 microglobulin is a 12 KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
    产品信息
    格式 Purified
    演示 The monoclonal is presented as 1mg of purified antibody in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Detect β-2 Microglobulin using this Anti-β-2 Microglobulin Antibody, clone C21 validated for use in ELISA.
    主要应用
    • ELISA
    应用说明 Study and detection of (-2 immunoglobulin in myeloma and other conditions

    Development of assay kits when used in conjunction with CBL 307 since both antibodies recognize different epitopes on the (-2 microglobulin molecule

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 C21
    宿主 Mouse
    特异性 The antibody recognizes the "hidden determinant" of beta-2 microglobulin.
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004048.2
    Entrez基因汇总 Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (Gussow et al., 1987 [PubMed 3312414]).[supplied by OMIM]
    基因符号
    • beta-2-microglobin
    • B2M
    • beta-2-microglobulin
    • HDCMA22P
    • ORFNames=CDABP0092
    UniProt编号
    • P61769
    UniProt汇总 FUNCTION: SwissProt: P61769 # Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
    SIZE: 119 amino acids; 13715 Da
    SUBCELLULAR LOCATION: Secreted.
    PTM: Glycation of Ile-21 is observed in long-term hemodialysis patients.
    DISEASE:SwissProt: P61769 # Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    SIMILARITY: SwissProt: P61769 ## Belongs to the beta-2-microglobulin family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 1 mg

    merck millipore,默克密理博,CBL306,Anti-β-2 Microglobulin Antibody, clone C21

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